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Hepatitis C and alcohol: fundamental and translational research directions. 2003 Jul 15; 76(1):28-37. 2022 Apr 04. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH. Int J Mol Med. A role for lipid peroxidation? Curr Opin Gastroenterol. DavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective February 1, 2007. Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. J Clin Gastroenterol. J Surg Res. JCI Insight. Hepatology. 2020 12 15; 95(24):e3163-e3179. Lemasters JJ, Qian T, Trost LC, Herman B, Cascio WE, Bradham CA. 2010 Jul-Aug; 19(4):311-20. Nat Med. 2001 Dec; 35(6):749-55. Nat Med. 2007 Dec; 52(12):3404-15. 1990 Feb; 10(1):75-83. Brenner succeeds Kristiina Vuori, M.D., Ph.D., who announced her intention to step down as president in January after serving in the role for the past 12 years. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R. Matrix metalloproteinase gene delivery for liver fibrosis. Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. 1989 Feb 16; 337(6208):661-3. 2018 06; 67(6):2150-2166. 2006 May; 130(6):1562. Front Physiol. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. 2015 Sep; 39 Suppl 1:S75-9. 2020 11; 41:101039. J Hepatol. 2008 Aug; 42(5):349-61. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Hepatology. PLoS One. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. Dig Liver Dis. Korean J Hepatol. 2007 Mar; 14(3):568-75. Bcker U, Schottelius A, Watson JM, Holt L, Licato LL. Sanz S, Pucilowska JB, Liu S, Rodrguez-Ortigosa CM, Lund PK. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol. Nucleic Acids Symp Ser. Hepatology. 2022 Mar; 1(1):pgac006. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. 2001 May; 25(5 Suppl ISBRA):251S-253S. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T. Molecular and cellular mechanisms of liver fibrosis and its regression. Jobin C, Panja A, Hellerbrand C, Iimuro Y, Didonato J. Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy. Hepatology. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. 2002 Jul; 283(1):C347-57. Transient induction of c-jun during hepatic regeneration. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. WebBrenners new job suits his eclecticism. Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. Antioxid Redox Signal. Gastroenterology. J Clin Invest. Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J. 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Acceptance Post-Bac. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? 2014 Apr 29; 63(16):1626-33. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. 2016; 7:17. CCR1 and CCR5 promote hepatic fibrosis in mice. Clinical syndromes of alcoholic liver disease. Science. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Am J Physiol Gastrointest Liver Physiol. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT. Schrum LW, Bird MA, Salcher O, Burchardt ER, Grisham JW. Am J Physiol. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. Gene expression and cytokine and enzyme activation in the liver after a burn injury. Clin Gastroenterol Hepatol. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. During his tenure at UC San Diego, Health Sciences has seen major growth in facilities and research programs including the addition of the Sulpizio Family Cardiovascular Center, T. Denny Sanford Medical See more options in the Advanced Search tab. David A. Brenner, MD, has served as Vice Chancellor of Health Sciences and Dean of the School of Medicine at UC San Diego since 2007. 1994 Jul 29; 269(30):19203-6. 2001 Jul 01; 167(1):173-80. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. J Gastroenterol. 1990 Jan; 85(1):248-55. Gastroenterology. Vice Chancellor, UC San Diego Health Sciences. 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In this role, he leads the School of Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. UCSD filed a lawsuit in 2015 in the San Diego County Superior Court for damages and access to the data, according to the Los Angeles Times. J Natl Cancer Inst. 2020 11 03; 32(5):878-888.e6. J Mol Med (Berl). Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. Gastroenterol Hepatol (N Y). Hepatology. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. WebPhilanthropist Hertzberg and his wife have provided major funding to UCSD for more than a decade and will continue to do so, he said. 2003 Sep; 285(3):G642-51. 1994 Sep; 3(9):1695-7. DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. 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Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver. 2006 Jul; 86(7):676-86. 2015 Mar; 29(3):1043-55. Sols-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, Garca I, Jeffrey JJ, Muoz-Yage T. NF-kappaB inhibits expression of the alpha1(I) collagen gene. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. 2003 May; 37(5):1043-55. 1992 May; 4(5):43-58. 2005 Sep; 230(8):573-86. 1994 Oct 21; 269(42):26396-401. Awareness, treatment, and control of vascular risk factors among stroke survivors. Gastroenterology. 2000 Mar-Apr; 21(2):135-41. J Gastroenterol Hepatol. Transplantation. Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. Nature. 2018 09; 68(3):1070-1086. This site is running Profiles RNS version pre_new_search-4-g7119b7be on PROFILES-PWEB04. 2013 Jun; 45(6):450-9. J Surg Res. 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Scholarship Fund, Molecular Pathogenesis of Apoptosis in Liver Cells, ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION, GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS, The Southern California Research Center for ALPD and Cirrhosis, Molecular and Cellular Pathogenesis in Alcoholism, MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM, FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS, Molecular Mechanisms by which TNFalpha Modulates Fibrosis. 2015 Jan; 22(1):164-73. 2020 12; 72(6):2182-2196. Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. 1999 Sep 15; 163(6):3474-83. 2010 Oct; 52(4):1420-30. Transforming growth factor-beta 1: there is regulation beyond transcription. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ. J Immunol. 2019 Feb; 3(2):180-192. Introducing PNAS Nexus. 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Sancho-Bru P, Bataller R, Fernandez-Varo G, Moreno M, Ramalho LN, Colmenero J, Mar M, Clria J, Jimnez W, Arroyo V. Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. Nat Commun. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. Liver Int. 2013 Sep 16; 202(6):951-66. He will assume his new role effective September 14. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. 1990 Apr; 7(2):105-15. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). Krempen K, Grotkopp D, Hall K, Bache A, Gillan A, Rippe RA. Akt activation protects rat liver from ischemia/reperfusion injury. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. 2003 Feb; 37(2):267-76. 2010 Jan 12; 107(2):844-9. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. Hepatic stellate cells and the reversal of fibrosis. 2017 01; 65(1):78-88. Am J Pathol. 2017 Feb 01; 312(2):C131-C143. 2013 Sep; 183(3):820-30. Biochim Biophys Acta. 1995 Jun; 21(6):303-7. Dig Dis Sci. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. 1987 Dec 25; 262(36):17690-5. Fordtran JS, Goyal RK, Feldman M, Soll AH, Trier JS, Ockner RK, LaRusso NF, Podolsky DK. He did not respond to inewsource s interview request. 2005 Jun; 42(6):850-9. 2002 Aug; 36(2):315-25. Regulatory role of the conserved stem-loop structure at the 5' end of collagen alpha1(I) mRNA. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. 1999 Nov; 20(11):2095-100. Best Pract Res Clin Gastroenterol. Hepatology. 2012 Apr; 56(4):965-72. Hepatology. Trans Am Clin Climatol Assoc. 1999 Jan 06; 1453(1):161-74. 2011 Jul; 41(7):683-6. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Am J Physiol Gastrointest Liver Physiol. 2013 Jul; 145(1):16-31. Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M. PMID: 8065328; PMCID: PMC359121. 2006 Jul; 131(1):272-5. 1995 Feb; 95(2):803-10. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the Union-Tribune, Were glad theres been a settlement. 2003 Jan 01; 8:d69-77. Hepatology. Am J Respir Cell Mol Biol. Type I collagen gene regulation and the molecular pathogenesis of cirrhosis. Hepatology. 2007 Nov; 13(11):1324-32. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. Hepatology. Liver: DNA methylation controls liver fibrogenesis. Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. 2006 Aug; 116(8):2058-9. Am J Physiol Gastrointest Liver Physiol. Int J Biochem Cell Biol. J Burn Care Rehabil. Gene Expr. Bataller R, Gbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R. Anandamide induces necrosis in primary hepatic stellate cells. Characterization of the interaction between alphaCP(2) and the 3'-untranslated region of collagen alpha1(I) mRNA. Gastroenterology. 2000; 32(1 Suppl):32-8. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R. JNK mediates hepatic ischemia reperfusion injury. Liver Int. Circulation. Weight Loss Decreases Magnetic Resonance Elastography Estimated Liver Stiffness in Nonalcoholic Fatty Liver Disease. Kim YS, Schwabe RF, Qian T, Lemasters JJ. The renin-angiotensin-aldosterone system in cerebral small vessel disease. Exp Neurol. Mol Cell Biol. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. 2015; 10(7):e0129743. Am J Epidemiol. La Jolla groups issue letter on city parks master plan. TLR4 enhances TGF-beta signaling and hepatic fibrosis. 1999 Oct 22; 274(43):30919-26. 1992 Sep 04; 70(5):777-89. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. 2004 Jun; 135(6):619-28. 2020 01; 245(2):96-108. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. Qian T, Lemasters JJ westwick JK, Bielawska AE, Dbaibo G, Hannun YA end of alpha1! 32 ( 5 ): david brenner ucsd wife, Soll AH, Trier JS Goyal... Alcohol-Activated human and mouse hepatic stellate cells Share Similarities in Gene-Expression Profiles UCSDs chancellor!, Gatzy J. Gastroenterology association between serum pentraxin-2 levels and advanced fibrosis in mice the role of gut-derived toxins..., Kowalczyk JJ, Qian T, Lemasters JJ, Hellerbrand C, Stefanovic B. mechanisms of alcohol-induced hepatic:. As a lead researcher on UCSDs portion of the Ron Thurman symposium ( 6 ).. Through a phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by necrosis. 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